Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904895 | 0.89 | GSK3B (0.48) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2904013 | 0.89 | GSK3B (0.52) | GSK3BGSK3ACDK1CYP19A1MAPT | |
| SCHEMBL2908870 | 0.88 | GSK3B (0.48) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2910340 | 0.88 | GSK3B (0.53) | GSK3BGSK3ACDK1CYP19A1MAPT | |
| SCHEMBL2907721 | 0.87 | GSK3B (0.49) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2912039 | 0.87 | GSK3B (0.48) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2912010 | 0.86 | GSK3B (0.49) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2911549 | 0.85 | GSK3B (0.47) | GSK3BGSK3ACDK1MAPTSMN1; SMN2 | |
| SCHEMBL2910865 | 0.85 | LMNA (0.53) | GSK3BGSK3ACDK1MAPTLMNA | |
| SCHEMBL2907434 | 0.85 | GSK3B (0.48) | GSK3BGSK3ACDK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |