Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543952 | 0.82 | HRH4 (0.57) | HRH4 | |
| SCHEMBL3950574 | 0.78 | HRH4 (0.46) | HRH4SSTR2KCNH2 | |
| SCHEMBL4537534 | 0.74 | HRH4 (0.50) | HRH4 | |
| SCHEMBL2907035 | 0.74 | HRH4 (0.70) | HRH4 | |
| SCHEMBL16266191 | 0.72 | HRH4 (0.59) | HRH4SSTR2KCNH2 | |
| SCHEMBL3897392 | 0.70 | HRH4 (0.49) | HRH4SSTR2KCNH2 | |
| SCHEMBL3478547 | 0.70 | KCNH2 (0.36) | SSTR2KCNH2EGFR | |
| SCHEMBL602161 | 0.68 | HRH4 (0.71) | HRH4 | |
| SCHEMBL4543946 | 0.68 | HRH4 (0.66) | HRH4 | |
| SCHEMBL2906733 | 0.67 | HRH4 (0.69) | HRH4SSTR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007752-B1 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-18 | — | — | EP | claimed |