Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 8/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3950565 | 0.83 | HRH4 (0.54) | HRH4SSTR5SSTR2KCNH2 | |
| SCHEMBL16266191 | 0.82 | HRH4 (0.59) | HRH4SSTR2KCNH2 | |
| SCHEMBL4543952 | 0.82 | HRH4 (0.57) | HRH4SSTR5 | |
| SCHEMBL2911883 | 0.78 | HRH4 (0.41) | HRH4SSTR2KCNH2 | |
| SCHEMBL3897392 | 0.76 | HRH4 (0.49) | HRH4SSTR5SSTR2KCNH2 | |
| SCHEMBL4537534 | 0.73 | HRH4 (0.50) | HRH4SSTR5 | |
| SCHEMBL2914884 | 0.72 | HRH4 (0.84) | HRH4 | |
| SCHEMBL16266193 | 0.69 | HRH4 (0.66) | HRH4SSTR2KCNH2 | |
| SCHEMBL4080120 | 0.68 | PARP1 (0.41) | HRH4SSTR5KCNH2 | |
| SCHEMBL17808691 | 0.66 | HRH4 (0.80) | HRH4SSTR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007752-A4 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-22 | — | — | EP | claimed |
| EP-2007752-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-31 | — | — | EP | claimed |
| WO-2007117399-A2 | BENZOIMIDAZOL-2-YL PYRIMIDINES AND PYRAZINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-18 | — | — | WO | claimed |