Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241557 | 0.91 | HTR2A (0.50) | HTR2AHTR2CHTR2BSIRT6MAPT | |
| SCHEMBL2245425 | 0.80 | GRIN2D (0.44) | MAPTNPC1POLBRAB9ALMNA | |
| SCHEMBL2245003 | 0.80 | GRIN2D (0.41) | MAPTPOLBRAB9ALMNAALDH1A1 | |
| SCHEMBL13006229 | 0.79 | GRIN2D (0.40) | MAPTPOLBRAB9ALMNAALDH1A1 | |
| SCHEMBL13688049 | 0.77 | BAZ2B (0.47) | HTR2AHTR2CHTR2BMAPTPOLB | |
| SCHEMBL29119413 | 0.76 | HTR2C (0.55) | HTR2AHTR2CHTR2BSIRT6MAPT | |
| SCHEMBL22445573 | 0.76 | NR1H2 (0.40) | HTR2AHTR2CHTR2BMAPTNPC1 | |
| SCHEMBL11331930 | 0.73 | BAZ2B (0.43) | MAPTL3MBTL1POLBLMNAALDH1A1 | |
| SCHEMBL10921359 | 0.72 | HTR2A (1.00) | HTR2AHTR2CHTR2BSIRT6MAPT | |
| SCHEMBL4887016 | 0.72 | MAPT (0.48) | SIRT6MAPTPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |