Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.55 |
| ▸ | HTR2A | P28223 | 9/20 | 0.55 |
| ▸ | HTR2B | P41595 | 9/20 | 0.55 |
| ▸ | PNMT | P11086 | 4/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | CD44 | P16070 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245003 | 0.81 | GRIN2D (0.41) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL2245425 | 0.81 | GRIN2D (0.44) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL11332933 | 0.80 | PNMT (0.45) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| SCHEMBL13006229 | 0.80 | GRIN2D (0.40) | MEN1KMT2AUSP2KEAP1NFE2L2 | |
| SCHEMBL29119458 | 0.76 | HTR2A (0.56) | HTR2CHTR2AHTR2BADRA2AMEN1 | |
| SCHEMBL2241557 | 0.71 | HTR2A (0.50) | HTR2CHTR2AHTR2BMEN1KMT2A | |
| SCHEMBL6097017 | 0.70 | HTR2C (0.62) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| SCHEMBL3600557 | 0.70 | PNMT (0.49) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| SCHEMBL22445620 | 0.70 | PNMT (0.52) | HTR2CHTR2AHTR2BPNMTADRA2A | |
| SCHEMBL3606170 | 0.70 | HTR2A (0.50) | HTR2CHTR2AHTR2BPNMTADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |