Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791536 | 0.88 | ALK (0.56) | ALKINSRMAP4K1 | |
| SCHEMBL24620226 | 0.88 | ALK (0.56) | ALKINSRMAP4K1 | |
| SCHEMBL30833017 | 0.87 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL24620274 | 0.87 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL24620201 | 0.87 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL30833048 | 0.87 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL24620377 | 0.87 | ALK (0.57) | ALKINSRMAP4K1 | |
| SCHEMBL30833012 | 0.87 | ALK (0.57) | ALKINSRMAP4K1 | |
| SCHEMBL24620253 | 0.83 | ALK (0.64) | ALKINSRMAP4K1 | |
| SCHEMBL29791331 | 0.83 | ALK (0.64) | ALKINSRMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116940565-A | Isoindolinone aminopyrimidine compounds as inhibitors of NUAK kinase, compositions and uses thereof | 安大略省癌症研究所(OICR) | 2023-10-24 | — | — | CN | disclosed |