Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 11/20 | 0.47 |
| ▸ | CDK7 | P50613 | 7/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.47 |
| ▸ | CDK9 | P50750 | 5/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.47 |
| ▸ | CCNH | P51946 | 5/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | CCNK | O75909 | 3/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911182 | 0.88 | CDK1 (0.47) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2913463 | 0.87 | CDK2 (0.61) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2914173 | 0.85 | CDK2 (0.43) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2914246 | 0.84 | CDK2 (0.39) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2912848 | 0.83 | CDK2 (0.47) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2913275 | 0.81 | CDK2 (0.47) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2912281 | 0.80 | CDK2 (0.49) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2910932 | 0.80 | CDK2 (0.46) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL2907818 | 0.79 | CDK2 (0.49) | CDK1CCNB1CDK2CCNE1CDK9 | |
| SCHEMBL2910257 | 0.79 | CDK2 (0.63) | CDK1CCNB1CCNB2CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF | 2005-04-14 | — | — | US | disclosed |
| WO-2003082872-A1 | NOVEL PYRAZOLO[4,3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS FOR THERAPY | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC) (CZ) | 2003-10-09 | — | — | WO | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | CBR3, DHFR, AKR1C3 | CDK1 1081/4885CCNB1 682/4885CCNB2 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.