SCHEMBL2912479

SCHEMBL2912479

Cc1cc(C)cc(NC(=O)c2cc(C(=O)Nc3cc(C)cc(C)c3)cc(C(=O)Nc3cc(C)cc(C)c3)c2)c1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.78
TDP1 Q9NUW8 1/20 0.59
KMT2A Q03164 5/20 0.58
MEN1 O00255 4/20 0.58
RXFP1 Q9HBX9 1/20 0.58
NPC1 O15118 3/20 0.57
RAB9A P51151 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
LMNA P02545 1/20 0.57
KDM4E B2RXH2 3/20 0.53
MAPT P10636 3/20 0.53
ALDH1A1 P00352 2/20 0.53
HPGD P15428 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
USP2 O75604 1/20 0.51
MAPK1 P28482 1/20 0.51
HTT P42858 2/20 0.51
SCN10A Q9Y5Y9 2/20 0.50
P2RX1 P51575 1/20 0.50
TMPRSS4 Q9NRS4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31103466 0.95 THRB (0.71) THRBTDP1KMT2AMEN1RXFP1
SCHEMBL1949551 0.91 THRB (0.66) THRBTDP1KMT2AMEN1NPC1
SCHEMBL13719742 0.85 NPC1 (0.74) THRBTDP1KMT2AMEN1NPC1
SCHEMBL3274053 0.84 THRB (0.79) THRBTDP1KMT2AMEN1RXFP1
SCHEMBL5604593 0.82 KMT2A (0.69) THRBTDP1KMT2AMEN1NPC1
SCHEMBL15427597 0.82 THRB (0.66) THRBTDP1KMT2AMEN1NPC1
SCHEMBL6556053 0.82 NQO2 (0.70) THRBTDP1KMT2AMEN1NPC1
SCHEMBL94626 0.81 THRB (0.64) THRBTDP1KMT2AMEN1RXFP1
SCHEMBL15653603 0.81 TDP1 (0.67) THRBTDP1KMT2AMEN1NPC1
SCHEMBL12218322 0.81 SCN10A (0.65) THRBKMT2AMEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732198-B2 Mono- and multi-layer blown films BASF SE (DE) 2017-08-15 US disclosed
US-20170081486-A1 Mono- and Multi-Layer Blown Films BASF SE (DE) 2017-03-23 US disclosed
US-20160136871-A1 Mono- and Multi-Layer Blown Films BASF SE (DE) 2016-05-19 US disclosed
US-9278487-B2 Mono-and multi-layer blown films BASF SE (DE) 2016-03-08 US disclosed
US-8492468-B2 Polypropylene resin composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-07-23 US disclosed
US-20130161875-A1 MONO-AND MULTI-LAYER BLOWN FILMS BASF SE (DE) 2013-06-27 US disclosed
US-20110301268-A1 POLYPROPYLENE RESIN COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-12-08 US disclosed
EP-2026965-B1 MONO- AND MULTI-LAYER BLOWN FILMS BASF SE (DE) 2010-09-01 EP disclosed
US-20090208718-A1 Mono-and multi-layer blown films CIBA CORP. 2009-08-20 US disclosed
US-7479515-B2 Polypropylene resin compositions CIBA SPECIALTY CHEMICALS CORP. (US) 2009-01-20 US disclosed
US-20070170398-A1 Polypropylene resin compositions SCHMIDT HANS-WERNER 2007-07-26 US disclosed
US-7235191-B2 Crystallizable polypropylene homopolymer, random copolymer, alternating or segmented copolymer, block copolymer or a blend of polypropylene with another synthetic polymer, and b) 0.001 to 5% relative to the weight of component (a), of a specific CIBA SPECIALTY CHEMICALS CORP. (US) 2007-06-26 US disclosed
EP-1366116-B1 POLYPROPYLENE RESIN COMPOSITIONS CIBA SC HOLDING AG (CH) 2006-07-19 EP disclosed
US-20040063830-A1 Crystallizable polypropylene homopolymer, random copolymer, alternating or segmented copolymer, block copolymer or a blend of polypropylene with another synthetic polymer, and b) 0.001 to 5% relative to the weight of component (a), of a specific CIBA SPECIALTY CHEMICALS CORPORATION 2004-04-01 US disclosed