Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 6/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127339 | 0.90 | STAT6 (0.52) | STAT6JAK2JAK1MAPK1TP53 | |
| SCHEMBL28887528 | 0.87 | STAT6 (0.44) | STAT6JAK2JAK1MAPK1MAPT | |
| SCHEMBL28887591 | 0.83 | STAT6 (0.49) | STAT6JAK2JAK1MAPK1TP53 | |
| SCHEMBL28887535 | 0.83 | JAK3 (0.57) | STAT6JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887507 | 0.82 | JAK2 (0.41) | STAT6JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887598 | 0.78 | HPGD (0.41) | STAT6JAK2MAPK1TP53MAPT | |
| SCHEMBL28887604 | 0.78 | JAK1 (0.38) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL28887563 | 0.76 | JAK1 (0.44) | JAK2JAK1JAK3TYK2IGF1R | |
| SCHEMBL28887550 | 0.76 | JAK3 (0.57) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887505 | 0.76 | STAT6 (0.48) | STAT6JAK2JAK1MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |