Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127336 | 0.90 | STAT6 (0.54) | STAT6TP53MAPTMAPK1JAK2 | |
| SCHEMBL28887598 | 0.88 | HPGD (0.41) | STAT6TP53MAPTMAPK1JAK2 | |
| SCHEMBL28887550 | 0.84 | JAK3 (0.57) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887505 | 0.84 | STAT6 (0.48) | STAT6TP53MAPTMAPK1JAK2 | |
| SCHEMBL28887501 | 0.83 | JAK3 (0.56) | STAT6JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887603 | 0.82 | JAK2 (0.51) | MAPK1JAK2IGF1RJAK1JAK3 | |
| SCHEMBL29127340 | 0.80 | JAK2 (0.33) | STAT6JAK2JAK1JAK3CDK1 | |
| SCHEMBL28887528 | 0.80 | STAT6 (0.44) | STAT6MAPTMAPK1JAK2JAK1 | |
| SCHEMBL28887556 | 0.78 | JAK1 (0.43) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL28887601 | 0.77 | JAK1 (0.55) | JAK2IGF1RJAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |