SCHEMBL291279

SCHEMBL291279

[CH2]Cc1cnccn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3112201 0.84
SCHEMBL980114 0.80
SCHEMBL294804 0.80
SCHEMBL1521573 0.78 HSP90AA1 (0.43)
SCHEMBL293167 0.77 HSP90AA1 (0.34)
SCHEMBL3026031 0.75
SCHEMBL294018 0.75 HSP90AA1 (0.33)
SCHEMBL344601 0.74
SCHEMBL7692978 0.74
SCHEMBL284256 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 948 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527022-A Asymmetric polysulfide compound and its synthesis method and use 华东师范大学 2021-10-22 CN claimed
EP-3894396-A1 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS Ideaya Biosciences, Inc. (US) 2021-10-20 EP claimed
CN-113166078-A 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors 伊迪亚生物科学有限公司 2021-07-23 CN claimed
CN-106749268-B Heteroaromatic compounds and their use in medicine 广东东阳光药业有限公司 2020-10-09 CN claimed
WO-2020123395-A1 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. (US) 2020-06-18 WO claimed
CN-105085461-B A kind of flavane compound, preparation method and hypoglycemic activity 中国医学科学院药物研究所 2019-09-13 CN claimed
CN-110183867-A A kind of bridge modified asphalt material and preparation method thereof 石旭艳 2019-08-30 CN claimed
CN-107298682-A A kind of synthetic method of the 4,5,6,7 tetrahydro-pyrazoles simultaneously Ethyl formate of [1,5 A] pyrazine 2 天津药明康德新药开发有限公司 2017-10-27 CN claimed
CN-107235867-A It is used as the aryl sultam derivative of RORc conditioning agents 弗·哈夫曼-拉罗切有限公司 2017-10-10 CN claimed
CN-105025899-B Having a2AHeterobicyclically substituted- [1,2,4 ] antagonists]Triazolo [1,5-c]Quinazoline-5-amine compounds 默沙东公司 2017-08-18 CN claimed
US-5484811-A ADMINISTERING A RENIN INHIBITOR TO A SUBJECT G. D. SEARLE & CO. (US) 1996-01-16 US claimed
US-5484812-A ADMINISTERING A RENIN INHIBITOR TO A SUBJECT G.D. SEARLE & CO. (US) 1996-01-16 US claimed
EP-0610451-A1 ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1994-08-17 EP claimed
US-5330996-A Renin inhibitors G. D. SEARLE & CO. (US) 1994-07-19 US claimed
US-5227401-A ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G. D. SEARLE & CO. (US) 1993-07-13 US claimed
US-5223535-A Renin inhibitors G. D. SEARLE & CO. (US) 1993-06-29 US claimed
WO-1993009108-A1 AMINO ACYL AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1993-05-13 WO claimed
WO-1993009086-A1 PROPARGYL GLYCINE AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1993-05-13 WO claimed
WO-1993009087-A1 ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION G.D. SEARLE & CO. (US) 1993-05-13 WO claimed
EP-0539976-A1 Ethynyl-alanine-amino-diol compounds for treatment of hypertension G.D. Searle & Co. (US) 1993-05-05 EP claimed