Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Lidocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A known ✓ | Q9NY46 | 3/20 | 0.94 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.94 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.94 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.94 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.54 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | BLM | P54132 | 2/20 | 0.97 |
| ▸ | GAA | P10253 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.94 |
| ▸ | MC4R | P32245 | 1/20 | 0.94 |
| ▸ | MC3R | P41968 | 1/20 | 0.94 |
| ▸ | HTR3A | P46098 | 1/20 | 0.94 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lidocaine SCHEMBL5159066 | 0.98 | MAPT (1.00) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL9113024 | 0.98 | MAPT (1.00) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL9516184 | 0.98 | MAPT (0.97) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL29130 | 0.98 | MAPT (1.00) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL27076588 | 0.98 | MAPT (0.97) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL20599347 | 0.97 | MAPT (0.97) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL27387919 | 0.97 | MAPT (0.97) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL15689 | 0.97 | MAPT (1.00) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL8183082 | 0.97 | MAPT (1.00) | MAPTLMNABLMGAASCN3A | |
| Lidocaine SCHEMBL5334354 | 0.97 | MAPT (1.00) | MAPTLMNABLMGAASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18181 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075865-A | Airway management apparatus with local anesthetic film and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080445-A | Sodium hyaluronate gel and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122057064-A | Multifunctional composite hemostatic powder capable of achieving wound in-situ self-gelation and preparation method thereof | 杨鑫 | 2026-05-19 | — | — | CN | claimed |
| CN-122031677-A | Leptin receptor agonist antibodies for the treatment of metabolic dysfunction or hypoleptinemia | 瑞泽恩制药公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122005915-A | Antibiotic bioactive glass and preparation method thereof | 山东秒亿通医学科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4731182-A1 | TOPICAL REGIMEN FOR TREATING COLD SORES | Haleon UK IP Limited (GB) | 2026-04-29 | — | — | EP | claimed |
| EP-4731181-A1 | TOPICAL COMPOSITIONS FOR TREATING COLD SORES | Haleon UK IP Limited (GB) | 2026-04-29 | — | — | EP | claimed |
| US-20260097044-A1 | ION PAIR LIQUID CRYSTAL FORMULATIONS FOR LONG-ACTING INJECTABLES OF POORLY SOLUBLE DRUGS | FORDOZ PHARMA CORP. (US) | 2026-04-09 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260021185-A1 | LOCAL ANESTHETIC SOLUTION FOR DENTAL AND/OR CONTRAST MEDIA USE | NEOCAINE LLC (US) | 2026-01-22 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| WO-1985003862-A1 | ANTIVIRAL PHARMACEUTICAL PREPARATIONS AND METHODS FOR THEIR USE | BRIGHAM, DANA (US) | 1985-09-12 | — | — | WO | claimed |
| EP-0154344-A2 | Antiviral pharmaceutical preparations and their use | Brigham, Dana (US) | 1985-09-11 | — | — | EP | claimed |
| EP-0136768-A2 | Composition and method for treatingskin lesions | Laboratorios Biochemie De Mexico S.A. DE C.V. (MX) | 1985-04-10 | — | — | EP | claimed |
| US-4460360-A | Urethral anesthetic devices | FINEGOLD AARON N | 1984-07-17 | — | — | US | claimed |
| US-4439184-A | Two-dose syringe | CONCORD LABORATORIES, INC. (US) | 1984-03-27 | — | — | US | claimed |
| US-4432758-A | Urethral anesthetic devices | FINEGOLD AARON N | 1984-02-21 | — | — | US | claimed |
| EP-0060451-A1 | Iontophoretic electrode | MEDTRONIC, INC. (US) | 1982-09-22 | — | — | EP | claimed |
| US-4339452-A | ANTICOAGULANTS | MEDICHEMIE AG (CH) | 1982-07-13 | — | — | US | claimed |
| US-4213876-A | Multi-purpose blood diluent for use in electronic blood analysis instrumentation | COULTER ELECTRONICS, INC. (US) | 1980-07-22 | — | — | US | claimed |