Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | CA9 | Q16790 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25693853 | 0.90 | PTPN11 (0.67) | PTPN11DDB1CRBNADRA2ADRD5 | |
| SCHEMBL27222955 | 0.85 | CA1 (0.42) | PTPN11DDB1CRBNCA12CA1 | |
| SCHEMBL24630469 | 0.83 | PTPN11 (0.66) | PTPN11DDB1CRBNADRA2ADRD5 | |
| SCHEMBL24510789 | 0.81 | PTPN11 (0.40) | PTPN11CA12CA1CA2CA9 | |
| SCHEMBL3666693 | 0.80 | ALDH1A1 (0.49) | PTPN11DDB1CRBNCA12CA1 | |
| SCHEMBL12380408 | 0.78 | MEN1 (0.49) | PTPN11 | |
| SCHEMBL26131987 | 0.77 | PTPN11 (0.64) | PTPN11DDB1CRBNADRA2ADRD5 | |
| SCHEMBL31747254 | 0.77 | PTPN11 (0.64) | PTPN11DDB1CRBNADRA2ADRD5 | |
| SCHEMBL11997705 | 0.76 | PTPN11 (0.67) | PTPN11DDB1CRBNADRA2ADRD5 | |
| SCHEMBL13290619 | 0.76 | PTPN11 (0.67) | PTPN11DDB1CRBNADRA2ADRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117279636-A | Methods and compounds for modulating myotonic muscular dystrophy type 1 | 设计治疗公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117241805-A | Methods and compounds for treating friedel-crafts ataxia | 设计治疗公司 | 2023-12-15 | — | — | CN | disclosed |
| EP-4274583-A2 | METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-4259133-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022126000-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2022-06-16 | — | — | WO | disclosed |