SCHEMBL29129556

SCHEMBL29129556

COc1cccc2c(=O)c(S)c(-c3ccccc3)oc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 9/20 0.57
KDM4E B2RXH2 4/20 0.57
ALDH1A1 P00352 4/20 0.57
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
LMNA P02545 2/20 0.57
ABCG2 Q9UNQ0 2/20 0.50
ABCC1 P33527 1/20 0.50
CYP1A1 P04798 3/20 0.46
CYP1B1 Q16678 3/20 0.46
CYP1A2 P05177 2/20 0.46
MAPT P10636 3/20 0.46
CYP3A4 P08684 2/20 0.46
HPGD P15428 2/20 0.46
HSD17B10 Q99714 2/20 0.46
PKM P14618 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4282126 0.84 ABCG2 (0.69) MAOAKDM4EALDH1A1NPC1RAB9A
SCHEMBL1534501 0.83 MAOA (0.57) MAOAKDM4EALDH1A1NPC1RAB9A
SCHEMBL29129504 0.82 CYP1A1 (0.53) KDM4EALDH1A1NPC1RAB9AABCG2
SCHEMBL29129594 0.81 ABCG2 (0.44) MAOAKDM4EALDH1A1LMNAABCG2
SCHEMBL29129586 0.78 ABCG2 (0.43) KDM4EALDH1A1LMNAABCG2ABCC1
SCHEMBL29129512 0.78 TTR (0.46) KDM4EALDH1A1LMNAABCG2ABCC1
SCHEMBL25790311 0.78 MAOA (0.49) MAOAKDM4EALDH1A1NPC1RAB9A
SCHEMBL31234378 0.76 KDM4E (0.52) MAOAKDM4EALDH1A1NPC1RAB9A
Hydrochloric Acid SCHEMBL31572317 0.75 KDM4E (0.51) MAOAKDM4EALDH1A1NPC1RAB9A
SCHEMBL29129562 0.75 ABCG2 (0.41) KDM4EALDH1A1LMNAABCG2ABCC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117247370-A Method for synthesizing thioflavonoids based on alkyne thiocarboxyl 四川大学 2023-12-19 CN disclosed