Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Chlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chlorophenol SCHEMBL1230203 | 0.94 | TSHR (0.62) | TSHRLMNAALDH1A1CYP2A6CYP1A2 | |
| 2-Chlorophenol SCHEMBL3225047 | 0.94 | — | — | |
| 2-Chlorophenol SCHEMBL1230537 | 0.94 | TSHR (0.62) | TSHRLMNAALDH1A1CYP2A6CYP1A2 | |
| 2-Chlorophenol SCHEMBL1229280 | 0.94 | TSHR (0.62) | TSHRLMNAALDH1A1CYP2A6CYP1A2 | |
| 2-Chlorophenol SCHEMBL6065580 | 0.94 | — | — | |
| 2-Chlorophenol SCHEMBL6763626 | 0.94 | — | — | |
| 2-Chlorophenol SCHEMBL31616214 | 0.94 | — | — | |
| 2-Chlorophenol SCHEMBL11881746 | 0.91 | TSHR (0.59) | TSHRLMNAALDH1A1CYP2A6CYP1A2 | |
| 1,2-Dichlorobenzene SCHEMBL7440616 | 0.79 | TSHR (0.83) | TSHRLMNAALDH1A1CYP2A6CYP1A2 | |
| 1,2-Dichlorobenzene SCHEMBL10593125 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573739-B | solid titanium catalyst | 中国石油天然气股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116410384-A | HDPE copolymer and preparation method and application thereof | 中国石油天然气股份有限公司 | 2023-07-11 | — | — | CN | disclosed |