SCHEMBL29130792

SCHEMBL29130792

Cc1cc(C(=O)O)cc(C(=O)c2[nH]c(=O)[nH]c(=O)c2C(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.42
LMNA P02545 2/20 0.38
MAPT P10636 2/20 0.38
HCAR1 Q9BXC0 1/20 0.38
JAK2 O60674 1/20 0.34
THRB P10828 1/20 0.34
PDE3B Q13370 3/20 0.33
PDE3A Q14432 3/20 0.33
PDE4A P27815 2/20 0.33
PDE4B Q07343 2/20 0.33
PDE4C Q08493 2/20 0.33
PDE4D Q08499 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
NFKB1 P19838 1/20 0.33
BLM P54132 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30692754 1.00 TPMT (0.42) TPMTLMNAMAPTHCAR1JAK2
SCHEMBL501939 0.92 MAPT (0.37) TPMTLMNAMAPTJAK2THRB
SCHEMBL30692755 0.88 ALDH1A1 (0.36) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL29130772 0.88 ALDH1A1 (0.36) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL10265038 0.86 ALDH1A1 (0.37) TPMTLMNAMAPTPDE3BPDE3A
SCHEMBL30747867 0.85 PDE3B (0.33) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL501621 0.85 TYMP (0.38) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL501255 0.85 PDE3B (0.33) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL13485635 0.85 PDE3B (0.33) LMNAMAPTPDE3BPDE3APDE4A
SCHEMBL501435 0.82 GRIN1 (0.33) PDE3BPDE3APDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117304118-A Synthesis method of anti-AIDS drug Ai Nuowei forest 江苏艾迪药业股份有限公司 2023-12-29 CN claimed
CN-117304118-A Synthesis method of anti-AIDS drug Ai Nuowei forest 江苏艾迪药业股份有限公司 2023-12-29 CN disclosed