Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30668832 | 1.00 | JAK2 (0.61) | JAK2ABL1PDGFRBBCRSRC | |
| SCHEMBL25699615 | 0.84 | GSK3B (0.61) | JAK2TYK2JAK1CDK9JAK3 | |
| SCHEMBL1641684 | 0.80 | JAK2 (0.43) | JAK2ABL1PDGFRBBCRSRC | |
| SCHEMBL1032453 | 0.80 | ABL1 (0.66) | JAK2ABL1PDGFRBBCRSRC | |
| SCHEMBL12726495 | 0.79 | ABL1 (0.50) | JAK2ABL1PDGFRBBCRSRC | |
| SCHEMBL13121374 | 0.79 | MAPT (0.52) | MAPTKMT2AL3MBTL1 | |
| SCHEMBL13120712 | 0.77 | MAPT (0.53) | JAK2ABL1PDGFRBBCRSRC | |
| SCHEMBL31380442 | 0.76 | AAK1 (0.52) | MAPT | |
| SCHEMBL29580206 | 0.76 | CNR1 (0.49) | CDK9MAPTMALT1 | |
| SCHEMBL28253313 | 0.76 | CNR1 (0.49) | CDK9MAPTMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117088851-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-11-21 | — | — | CN | disclosed |