SCHEMBL29131341

SCHEMBL29131341

[c]1cccc2c1cc(-c1cccc3cc4ccccc4cc13)c1ccccc12

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.37
KDM4E B2RXH2 3/20 0.37
GAA P10253 2/20 0.37
HSD17B10 Q99714 6/20 0.36
HPGD P15428 5/20 0.36
HIF1A Q16665 3/20 0.36
TSHR P16473 2/20 0.36
MAPK1 P28482 2/20 0.36
CASP1 P29466 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
CES1 P23141 1/20 0.35
CYP1B1 Q16678 1/20 0.34
CYP1A2 P05177 4/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
GLA P06280 1/20 0.33
CYP2C19 P33261 1/20 0.33
ERBB2 P04626 1/20 0.33
FYN P06241 1/20 0.33
MAOA P21397 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28538297 0.81 CES1 (0.38) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL3783406 0.80 ALDH1A1 (0.46) ALDH1A1HSD17B10HPGDHIF1ATSHR
SCHEMBL28376300 0.79 ALDH1A1 (0.55) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL14718717 0.78 ALDH1A1 (0.47) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL17136293 0.78 ALDH1A1 (0.36) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL5965314 0.78 CYP1A2 (0.41) ALDH1A1HSD17B10HPGDHIF1ATSHR
SCHEMBL1168422 0.78 ALDH1A1 (0.50) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL14322661 0.77 ALDH1A1 (0.48) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL2871930 0.76 ALDH1A1 (0.50) ALDH1A1KDM4EGAAHSD17B10HPGD
SCHEMBL29354014 0.76 ALDH1A1 (0.50) ALDH1A1KDM4EGAAHSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117304131-A Alpha-carbonyl alkenyl ester compound, and preparation method and application thereof 广州医科大学 2023-12-29 CN disclosed