Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 2/20 | 0.52 |
| ▸ | FNTB | P49356 | 2/20 | 0.52 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132085 | 0.88 | SIGMAR1 (0.59) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL12018092 | 0.85 | SIGMAR1 (0.62) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL29132334 | 0.85 | MEN1 (0.60) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL29132142 | 0.84 | FNTA (0.49) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL3976200 | 0.84 | MEN1 (0.59) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL3970461 | 0.84 | MEN1 (0.64) | MEN1KMT2ANPSR1SLC29A1SMN1; SMN2 | |
| SCHEMBL4588381 | 0.84 | MEN1 (0.64) | MEN1KMT2ANPSR1SLC29A1SMN1; SMN2 | |
| SCHEMBL5747411 | 0.83 | MEN1 (0.54) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL22418871 | 0.83 | SIGMAR1 (0.52) | FNTAFNTBPGGT1BMEN1KMT2A | |
| SCHEMBL31329561 | 0.82 | MEN1 (0.62) | MEN1KMT2ANPSR1SLC29A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |