Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25133223 | 0.85 | LRRK2 (0.36) | LRRK2TMEM97SIGMAR1NPC1DGAT1 | |
| SCHEMBL5518642 | 0.79 | NPC1 (0.36) | NPC1DGAT1 | |
| SCHEMBL21939036 | 0.78 | LRRK2 (0.46) | LRRK2TMEM97SIGMAR1 | |
| SCHEMBL24042714 | 0.76 | DGAT1 (0.34) | LRRK2TMEM97SIGMAR1NPC1DGAT1 | |
| SCHEMBL15574301 | 0.76 | NPC1 (0.43) | NPC1DGAT1 | |
| SCHEMBL30855567 | 0.76 | NPC1 (0.43) | NPC1DGAT1 | |
| SCHEMBL31391652 | 0.75 | DGAT1 (0.35) | NPC1DGAT1 | |
| SCHEMBL28999474 | 0.75 | DGAT1 (0.35) | NPC1DGAT1 | |
| SCHEMBL24042655 | 0.74 | LRRK2 (0.56) | LRRK2TMEM97SIGMAR1 | |
| SCHEMBL16025062 | 0.73 | LRRK2 (0.31) | LRRK2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |