Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25133987 | 1.00 | GPR119 (0.52) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL5210640 | 0.96 | GPR119 (0.55) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL29132139 | 0.94 | GPR119 (0.57) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL25133837 | 0.94 | GPR119 (0.57) | GPR119HPGDRECQLEPHX1KDM4E | |
| Hydrochloric Acid SCHEMBL27003917 | 0.94 | GPR119 (0.54) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL25628279 | 0.89 | GPR119 (0.48) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL15000457 | 0.89 | GPR119 (0.49) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL19297519 | 0.89 | GPR119 (0.49) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL13128899 | 0.89 | GPR119 (0.49) | GPR119HPGDRECQLEPHX1KDM4E | |
| SCHEMBL31540076 | 0.88 | GPR119 (0.47) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665456-A1 | BENZIMIDAZOLE AND BENZIMIDAZOLONE BASED PROTAC COMPOUNDS FOR THE TARGETED DEGRADATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) | Arvinas Operations, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2025072629-A1 | BENZIMIDAZOLE AND BENZIMIDAZOLONE BASED PROTAC COMPOUNDS FOR THE TARGETED DEGRADATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) | ARVINAS OPERATIONS, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |