Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 7/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 4/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | IL1B | P01584 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25238550 | 0.94 | MAP1LC3B (0.56) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL30042173 | 0.94 | MAP1LC3B (0.56) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL26814281 | 0.86 | CRBN (0.54) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL24830078 | 0.86 | TNF (0.56) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL25905191 | 0.85 | MAP1LC3B (0.66) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL29132183 | 0.85 | STAT3 (0.57) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL29928281 | 0.85 | STAT3 (0.57) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| Hydrochloric Acid SCHEMBL25327075 | 0.85 | MAP1LC3B (0.65) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL22959759 | 0.84 | MAP1LC3B (0.53) | MAP1LC3BCRBNIKZF1TNFIKZF3 | |
| SCHEMBL29132232 | 0.84 | MAP1LC3B (0.50) | MAP1LC3BCRBNTNFIKZF3STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |