Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132227 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| Hydrochloric Acid SCHEMBL29170427 | 0.89 | SIGMAR1 (0.56) | SMN1; SMN2CYP2C19NPC1RAB9ASIGMAR1 | |
| SCHEMBL29132158 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL22497996 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13661150 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL6584365 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL13661312 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL27012546 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP2C19NPC1RAB9AGRIN2B | |
| SCHEMBL335166 | 0.81 | MEN1 (0.59) | SMN1; SMN2CYP2C19NPC1RAB9ASIGMAR1 | |
| SCHEMBL29132278 | 0.81 | SIGMAR1 (0.57) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |