Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.58 |
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.50 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910733 | 0.89 | CDK2 (0.52) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2912812 | 0.88 | PPARG (0.49) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2910995 | 0.87 | CDK2 (0.52) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2912272 | 0.83 | CDK2 (0.51) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2910614 | 0.82 | PPARG (0.45) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2913249 | 0.82 | CDK2 (0.68) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2913189 | 0.81 | CDK2 (0.70) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL2911505 | 0.79 | NPY5R (0.50) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3720176 | 0.79 | TACR2 (0.49) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3725653 | 0.79 | CDK2 (0.46) | CDK1CDK2CCNB1CCNB2CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |