Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31336573 | 0.72 | HPGD (0.39) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL29062973 | 0.71 | SMN1; SMN2 (0.34) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL4188553 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL26130688 | 0.67 | HPGD (0.37) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL5010747 | 0.66 | ALDH1A1 (0.41) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL3631443 | 0.64 | ALDH1A1 (0.44) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL20051886 | 0.64 | SMN1; SMN2 (0.42) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL27902866 | 0.64 | HPGD (0.58) | HPGDMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16965092 | 0.64 | ALDH1A1 (0.42) | HPGDNPC1MAPTHTTRAB9A | |
| SCHEMBL5412873 | 0.64 | ALDH1A1 (0.42) | HPGDNPC1MAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |