SCHEMBL29133736

SCHEMBL29133736

N#Cc1cnc2ccc(-c3n[nH]c4ccncc34)cc2c1NCCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
HSD17B10 Q99714 2/20 0.41
CLK4 Q9HAZ1 2/20 0.41
CCNC P24863 2/20 0.41
CDK8 P49336 2/20 0.41
MAPK1 P28482 3/20 0.40
MAPK3 P27361 1/20 0.40
MAP3K8 P41279 1/20 0.40
EGFR P00533 5/20 0.40
PRKDC P78527 4/20 0.40
SRC P12931 2/20 0.40
ABL1 P00519 1/20 0.40
FLT1 P17948 1/20 0.40
KDR P35968 1/20 0.40
SYK P43405 1/20 0.40
PIK3CA P42336 1/20 0.39
CDKN1A P38936 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29133790 0.93 EGFR (0.42) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133710 0.82 CYP1A2 (0.52) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL24576702 0.80 EGFR (0.63) ALDH1A1MAPK1MAP3K8EGFRPRKDC
SCHEMBL29133738 0.78 CCNC (0.47) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133731 0.77 EGFR (0.63) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133709 0.77 EGFR (0.49) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133741 0.77 EGFR (0.66) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133767 0.77 EGFR (0.44) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133717 0.76 EGFR (0.50) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL29133761 0.76 EGFR (0.51) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117295716-A Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors 麦克尼斯迪克治疗有限公司 2023-12-26 CN disclosed