Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29133748 | 0.91 | EGFR (0.47) | EGFRPIK3CAPRKDCPIK3CDPIK3CB | |
| SCHEMBL29133759 | 0.85 | EGFR (0.57) | EGFRPIK3CA | |
| SCHEMBL29133787 | 0.83 | PIK3CA (0.58) | EGFRPIK3CAPRKDCPIK3CDPIK3CB | |
| SCHEMBL29133728 | 0.81 | IRAK4 (0.48) | EGFR | |
| SCHEMBL29133764 | 0.80 | PIK3CA (0.37) | EGFRPIK3CAPRKDCPIK3CDPIK3CB | |
| SCHEMBL29133711 | 0.79 | PIK3CA (0.41) | EGFRPIK3CA | |
| SCHEMBL29133716 | 0.78 | IRAK4 (0.39) | EGFR | |
| SCHEMBL29133742 | 0.78 | IRAK4 (0.35) | PIK3CAPIK3CD | |
| SCHEMBL29133774 | 0.77 | IRAK4 (0.47) | EGFRPIK3CA | |
| SCHEMBL24609222 | 0.77 | EGFR (0.68) | EGFRPIK3CAPRKDCPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295716-A | Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors | 麦克尼斯迪克治疗有限公司 | 2023-12-26 | — | — | CN | disclosed |