Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.58 |
| ▸ | EGFR | P00533 | 7/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29133776 | 0.83 | EGFR (0.58) | PIK3CAEGFRPIK3CGPRKDCPIK3CD | |
| SCHEMBL29133729 | 0.83 | EGFR (0.52) | PIK3CAEGFRPRKDC | |
| SCHEMBL29133758 | 0.81 | EGFR (0.42) | PIK3CAEGFRPIK3CGPRKDCPIK3CD | |
| SCHEMBL29133713 | 0.81 | EGFR (0.44) | PIK3CAEGFRPIK3CGMTORPRKDC | |
| SCHEMBL29133718 | 0.81 | MELK (0.49) | EGFR | |
| SCHEMBL29133769 | 0.80 | PIK3CA (0.46) | PIK3CAPIK3CGMTORPIK3CDPIK3CB | |
| SCHEMBL29133737 | 0.80 | MAP4K4 (0.42) | PIK3CAEGFRPIK3CGPRKDC | |
| SCHEMBL29133757 | 0.80 | EGFR (0.55) | PIK3CAEGFRMTORPRKDCPIK3CD | |
| SCHEMBL29133705 | 0.80 | EGFR (0.41) | PIK3CAEGFRPRKDC | |
| SCHEMBL29133763 | 0.79 | MELK (0.38) | PIK3CAEGFRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295716-A | Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors | 麦克尼斯迪克治疗有限公司 | 2023-12-26 | — | — | CN | disclosed |