Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F11 | P03951 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 3/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29134439 | 1.00 | AAK1 (0.50) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL15775010 | 0.89 | AAK1 (0.53) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL2558922 | 0.84 | AAK1 (0.55) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL1141382 | 0.84 | AAK1 (0.55) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL2592224 | 0.84 | AAK1 (0.55) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL19813403 | 0.82 | F11 (0.43) | AAK1F2F11PRSS1PRSS2 | |
| SCHEMBL2566663 | 0.81 | AAK1 (0.53) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL16793643 | 0.81 | AAK1 (0.53) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL15092585 | 0.81 | AAK1 (0.53) | AAK1PRMT5WDR77F2F11 | |
| SCHEMBL30664752 | 0.81 | AAK1 (0.53) | AAK1PRMT5WDR77F2F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |