SCHEMBL29134830

SCHEMBL29134830

N#Cc1ccc(Sc2cccc(Br)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.67
MAOA P21397 11/20 0.67
MCL1 Q07820 1/20 0.39
DHFR P00374 1/20 0.38
PLA2G1B P04054 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
TSHR P16473 1/20 0.35
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30015349 1.00 MAOB (0.67) MAOBMAOAMCL1DHFRPLA2G1B
SCHEMBL20132302 0.81 MAOB (1.00) MAOBMAOAMCL1DHFRTSHR
SCHEMBL11819273 0.81 MAOA (0.50) MAOBMAOAMCL1GRM5
SCHEMBL3289392 0.80 MAOA (0.48) MAOBMAOAGRM5
SCHEMBL29543964 0.80 MAOA (0.48) MAOBMAOAGRM5
SCHEMBL31337906 0.80 MAOA (0.48) MAOBMAOAGRM5
SCHEMBL920932 0.79 MAOA (0.63) MAOBMAOAMCL1DHFR
SCHEMBL3285262 0.78 HTR2C (0.47) MAOBMAOAMCL1TSHRGRM5
SCHEMBL2985023 0.78 MAOB (1.00) MAOBMAOAMCL1DHFRPLA2G1B
SCHEMBL30385602 0.78 HTR2C (0.47) MAOBMAOAMCL1TSHRGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117120429-A KHK inhibitor 吉利德科学公司 2023-11-24 CN disclosed