Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.50 |
| ▸ | EDNRA | P25101 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477853 | 0.87 | KDM1A (0.55) | EDNRBEDNRAKDM1AMEN1PLA2G1B | |
| SCHEMBL12749435 | 0.87 | KDM1A (0.55) | EDNRBEDNRAKDM1AMEN1PLA2G1B | |
| SCHEMBL1477468 | 0.87 | KDM1A (0.55) | EDNRBEDNRAKDM1AMEN1PLA2G1B | |
| SCHEMBL1477851 | 0.87 | KDM1A (0.55) | EDNRBEDNRAKDM1AMEN1PLA2G1B | |
| SCHEMBL16445521 | 0.82 | CYP19A1 (0.39) | EDNRBEDNRAOPRM1OPRD1OPRK1 | |
| SCHEMBL16450274 | 0.76 | KDM1A (0.50) | EDNRBEDNRAKDM1A | |
| SCHEMBL1478222 | 0.76 | KDM1A (0.50) | EDNRBEDNRAKDM1A | |
| SCHEMBL12749373 | 0.76 | KDM1A (0.50) | EDNRBEDNRAKDM1A | |
| SCHEMBL26656414 | 0.74 | OPRM1 (0.41) | EDNRBEDNRAMEN1PLA2G1BGAPDH | |
| SCHEMBL17276195 | 0.72 | EDNRB (0.41) | EDNRBEDNRAKDM1AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |