SCHEMBL29135539

SCHEMBL29135539

C=CCC=Cc1ccc(Cl)cc1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.46
CYP1A2 P05177 2/20 0.43
KCNH2 Q12809 2/20 0.42
HSD17B10 Q99714 2/20 0.41
FBP1 P09467 1/20 0.41
GRIK1 P39086 1/20 0.40
GRIK2 Q13002 1/20 0.40
GRIK3 Q13003 1/20 0.40
ALOX5 P09917 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38
NFE2L2 Q16236 1/20 0.38
MAOB P27338 2/20 0.37
LMNA P02545 1/20 0.36
CYP2A6 P11509 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38655029 0.88 ALDH1A1 (0.40) ALDH1A1
SCHEMBL2092199 0.79 AHR (0.48) AHRCYP1A2KCNH2HSD17B10FBP1
SCHEMBL2092197 0.79 AHR (0.48) AHRCYP1A2KCNH2HSD17B10FBP1
SCHEMBL7207019 0.79 AHR (0.48) AHRCYP1A2KCNH2HSD17B10FBP1
SCHEMBL9250076 0.77 APP (0.50) MAOB
SCHEMBL2090684 0.77 HSD17B10 (0.52) AHRCYP1A2KCNH2HSD17B10FBP1
SCHEMBL9250081 0.77 APP (0.50) MAOB
SCHEMBL9247763 0.77 APP (0.50) CYP1A2HSD17B10ALOX5PTGS1PTGS2
SCHEMBL9247768 0.77 APP (0.50) CYP1A2HSD17B10ALOX5PTGS1PTGS2
SCHEMBL73285 0.76 AHR (0.50) AHRCYP1A2KCNH2HSD17B10FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117304127-A Oxazoline derivative and preparation method and application thereof 南开大学 2023-12-29 CN disclosed