Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 12/20 | 0.49 |
| ▸ | MET | P08581 | 10/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885082 | 0.93 | INSR (0.53) | INSRMETALK | |
| SCHEMBL15403913 | 0.92 | INSR (0.50) | INSRMETALKMAPK9MAPK10 | |
| SCHEMBL2908827 | 0.92 | INSR (0.50) | INSRMETALKMAPK9MAPK10 | |
| SCHEMBL16966162 | 0.86 | INSR (0.48) | INSRMETALK | |
| SCHEMBL15404108 | 0.86 | INSR (0.50) | INSRMETALKMAPK9MAPK10 | |
| SCHEMBL2061516 | 0.85 | INSR (0.54) | INSRMETALK | |
| SCHEMBL885128 | 0.85 | INSR (0.54) | INSRMETALK | |
| SCHEMBL885354 | 0.84 | INSR (0.49) | INSRMETALKMAPK9MAPK10 | |
| SCHEMBL16966152 | 0.81 | INSR (0.48) | INSRMETALKMAPK9MAPK10 | |
| SCHEMBL885054 | 0.81 | INSR (0.54) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |