Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778465 | 1.00 | GRK2 (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL24617106 | 1.00 | GRK2 (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL24617654 | 0.91 | GRK2 (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL29135998 | 0.90 | GRK2 (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL24617477 | 0.90 | GCK (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL29779064 | 0.90 | GCK (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL24617474 | 0.90 | GCK (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL24617127 | 0.90 | GCK (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL29778451 | 0.90 | GRK2 (0.42) | GRK2GCKTSHRROCK2TAF1 | |
| SCHEMBL30656498 | 0.90 | GCK (0.42) | GRK2GCKTSHRROCK2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | claimed |
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |