Sugi Predict

Sugi Predict / Compounds / SCHEMBL29778451

SCHEMBL29778451

SCHEMBL29778451

CNC(=O)c1cccc([C@@H](C)n2cnc3cc(-c4cn[nH]c4Br)ccc3c2=O)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GRK2 P25098 3/20 0.42
▸ GCK P35557 1/20 0.39
▸ TSHR P16473 1/20 0.37
▸ ROCK2 O75116 3/20 0.36
▸ TAF1 P21675 1/20 0.35
▸ EGFR P00533 2/20 0.35
▸ TNIK Q9UKE5 1/20 0.34
▸ METAP2 P50579 1/20 0.34
▸ DDR2 Q16832 1/20 0.33
▸ USP5 P45974 1/20 0.33
▸ ATR Q13535 1/20 0.33
▸ ATRIP Q8WXE1 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ CECR2 Q9BXF3 1/20 0.33
▸ CYP17A1 P05093 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CDK8 P49336 1/20 0.32
▸ ROCK1 Q13464 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29135996 1.00 GRK2 (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL29135998 1.00 GRK2 (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL24617654 0.91 GRK2 (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL24617474 0.90 GCK (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL24617106 0.90 GRK2 (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL29778465 0.90 GRK2 (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL24617477 0.90 GCK (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL24617127 0.90 GCK (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL29779064 0.90 GCK (0.42) GRK2GCKTSHRROCK2TAF1
SCHEMBL29778418 0.90 GCK (0.42) GRK2GCKTSHRROCK2TAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF Genosco Inc. 2024-11-14 — — US claimed
CN-117136186-A Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof 盖诺斯克公司 2023-11-28 — — CN claimed
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 — — EP claimed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 — — WO claimed
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF Genosco Inc. 2024-11-14 — — US disclosed
CN-117136186-A Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof 盖诺斯克公司 2023-11-28 — — CN disclosed
EP-4274825-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2023-11-15 — — EP disclosed
WO-2022150381-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF Genosco Inc. (US) 2022-07-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240374582-A1 SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF ROCK2, ROCK1, MYLK3 GRK2 216/4885GCK 2994/4885TSHR 4258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.