Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656536 | 1.00 | TSHR (0.49) | TSHRUSP5HCAR3GRK2MAPT | |
| SCHEMBL29136078 | 1.00 | TSHR (0.49) | TSHRUSP5HCAR3GRK2MAPT | |
| SCHEMBL29136040 | 0.89 | TSHR (0.44) | TSHRUSP5GRK2MAPTMCL1 | |
| SCHEMBL29779029 | 0.89 | TSHR (0.44) | TSHRUSP5GRK2MAPTMCL1 | |
| SCHEMBL29136042 | 0.89 | TSHR (0.44) | TSHRUSP5GRK2MAPTMCL1 | |
| SCHEMBL31232321 | 0.86 | TSHR (0.46) | TSHRUSP5HCAR3GRK2KDM5A | |
| SCHEMBL29779038 | 0.86 | TSHR (0.46) | TSHRUSP5HCAR3GRK2KDM5A | |
| SCHEMBL29779156 | 0.81 | ALDH1A1 (0.38) | MAPTKDM5AKDM5BKDM4EKMT2A | |
| SCHEMBL29136061 | 0.81 | ALDH1A1 (0.38) | MAPTKDM5AKDM5BKDM4EKMT2A | |
| SCHEMBL22807529 | 0.77 | USP5 (0.49) | TSHRUSP5MAPTMCL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |