SCHEMBL29136202

SCHEMBL29136202

COc1cccc(Cn2[c]cc3ccccc32)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.55
SIGMAR1 Q99720 1/20 0.50
CMA1 P23946 1/20 0.49
POLB P06746 3/20 0.48
LPO P22079 3/20 0.47
HTR1A P08908 1/20 0.45
DRD2 P14416 1/20 0.45
HTR2B P41595 1/20 0.45
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 2/20 0.45
GAA P10253 1/20 0.44
MAPT P10636 3/20 0.43
LMNA P02545 1/20 0.43
TP53 P04637 1/20 0.43
MEN1 O00255 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TSHR P16473 1/20 0.42
HPGD P15428 1/20 0.42
MAPK1 P28482 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29136199 0.85 CCR2 (0.55) KMT2ASIGMAR1CMA1LPOKDM4E
SCHEMBL3091129 0.84 P2RX4 (0.48) SIGMAR1CMA1POLBKDM4EALDH1A1
SCHEMBL1201646 0.78 RECQL (0.44) KMT2ASIGMAR1CMA1ALDH1A1LMNA
SCHEMBL29136204 0.78 HTT (0.45) KMT2APOLBALDH1A1LMNAMEN1
SCHEMBL29136196 0.75 MAPT (0.43) KMT2ASIGMAR1CMA1POLBKDM4E
SCHEMBL30218812 0.75 KMT2A (0.63) KMT2ASIGMAR1CMA1POLBLPO
SCHEMBL6087249 0.75 KMT2A (0.63) KMT2ASIGMAR1CMA1POLBLPO
SCHEMBL3086229 0.73 CYP1A2 (0.39) POLBKDM4ETP53
SCHEMBL3079067 0.73 P2RX4 (0.44) KMT2APOLBKDM4EALDH1A1MAPT
SCHEMBL29136185 0.72 CCR2 (0.52) KMT2ACMA1POLBKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117003739-A Nitrogen-containing heterocyclic compound, preparation method and application thereof 安徽中医药大学 2023-11-07 CN disclosed