Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 3/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29136748 | 1.00 | KDM4E (0.42) | KDM4ETP53LRRK2PKMBLM | |
| SCHEMBL24738299 | 1.00 | KDM4E (0.42) | KDM4ETP53LRRK2PKMBLM | |
| SCHEMBL29136883 | 0.92 | KLKB1 (0.42) | LRRK2METTL3 | |
| SCHEMBL29304970 | 0.92 | KLKB1 (0.42) | LRRK2METTL3 | |
| SCHEMBL29136881 | 0.92 | KLKB1 (0.42) | LRRK2METTL3 | |
| SCHEMBL29879679 | 0.92 | KLKB1 (0.42) | LRRK2METTL3 | |
| SCHEMBL29136982 | 0.92 | KLKB1 (0.42) | LRRK2METTL3 | |
| SCHEMBL24738301 | 0.90 | LRRK2 (0.39) | LRRK2TRPM5MAP4K1LMNA | |
| SCHEMBL24738275 | 0.90 | LRRK2 (0.39) | LRRK2LPAR2TRPM5MAP4K1LMNA | |
| SCHEMBL29879831 | 0.90 | LRRK2 (0.39) | LRRK2TRPM5MAP4K1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |