Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.37 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.37 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29880248 | 1.00 | LRRK2 (0.37) | LRRK2ABL1KLKB1METTL3MAP4K1 | |
| SCHEMBL24738541 | 1.00 | LRRK2 (0.37) | LRRK2ABL1KLKB1METTL3MAP4K1 | |
| SCHEMBL29136775 | 1.00 | LRRK2 (0.37) | LRRK2ABL1KLKB1METTL3MAP4K1 | |
| SCHEMBL29302761 | 0.91 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29278062 | 0.91 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29278065 | 0.91 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29940239 | 0.91 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29878844 | 0.87 | TYK2 (0.33) | MAP4K1 | |
| SCHEMBL24738376 | 0.87 | TYK2 (0.33) | MAP4K1 | |
| SCHEMBL24737796 | 0.84 | MAP4K1 (0.33) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |