Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24738376 | 1.00 | TYK2 (0.33) | TYK2MAP4K1IKBKBJAK2ROCK2 | |
| SCHEMBL29136772 | 0.87 | LRRK2 (0.37) | MAP4K1 | |
| SCHEMBL29136775 | 0.87 | LRRK2 (0.37) | MAP4K1 | |
| SCHEMBL24738541 | 0.87 | LRRK2 (0.37) | MAP4K1 | |
| SCHEMBL29880248 | 0.87 | LRRK2 (0.37) | MAP4K1 | |
| SCHEMBL29940239 | 0.86 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29278062 | 0.86 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29302761 | 0.86 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL29278065 | 0.86 | GRM5 (0.34) | MAP4K1 | |
| SCHEMBL24737796 | 0.85 | MAP4K1 (0.33) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4585265-A2 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2025-07-16 | — | — | EP | disclosed |
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |