Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29136758 | 1.00 | TTR (0.47) | TTRAPPCA1CA2CA12 | |
| SCHEMBL29879341 | 1.00 | TTR (0.47) | TTRAPPCA1CA2CA12 | |
| SCHEMBL6821853 | 0.88 | CA12 (0.55) | TTRAPPCA1CA2CA12 | |
| SCHEMBL6821855 | 0.88 | CA12 (0.55) | TTRAPPCA1CA2CA12 | |
| SCHEMBL2850778 | 0.81 | TTR (0.47) | TTRAPPCA1CA2CA12 | |
| SCHEMBL2850780 | 0.81 | TTR (0.47) | TTRAPPCA1CA2CA12 | |
| SCHEMBL23380718 | 0.81 | AKR1C3 (0.50) | TTRAPPCA1CA2CA12 | |
| SCHEMBL3928784 | 0.81 | BACE1 (0.54) | TTRAPPCA1CA2CA12 | |
| SCHEMBL3928787 | 0.81 | BACE1 (0.54) | TTRAPPCA1CA2CA12 | |
| SCHEMBL29137029 | 0.80 | NPSR1 (0.56) | TTRAPPCA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |