Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29136877 | 1.00 | KMT2A (0.42) | KMT2AMEN1MAPTNPC1POLB | |
| SCHEMBL29878996 | 0.84 | MAP4K1 (0.39) | KMT2AMEN1MAPTNPC1POLB | |
| SCHEMBL29303339 | 0.84 | MAP4K1 (0.39) | KMT2AMEN1MAPTNPC1POLB | |
| SCHEMBL29137009 | 0.84 | MAPK14 (0.39) | KMT2AMEN1NPC1LMNASMN1; SMN2 | |
| SCHEMBL29137012 | 0.84 | MAPK14 (0.39) | KMT2AMEN1NPC1LMNASMN1; SMN2 | |
| SCHEMBL24737858 | 0.78 | TYK2 (0.41) | KMT2AMEN1NPC1LMNASMN1; SMN2 | |
| SCHEMBL29940136 | 0.78 | TYK2 (0.41) | KMT2AMEN1NPC1LMNASMN1; SMN2 | |
| SCHEMBL1704102 | 0.73 | KMT2A (0.50) | KMT2AMEN1MAPTNPC1POLB | |
| SCHEMBL30715078 | 0.69 | CCR1 (0.40) | KMT2AMEN1MAPTNPC1LMNA | |
| SCHEMBL29137064 | 0.69 | MAP4K1 (0.38) | LMNASMN1; SMN2ALDH1A1ITKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |