Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904199 | 0.81 | SYK (0.44) | SYKALDH1A1 | |
| SCHEMBL902723 | 0.78 | POLB (0.44) | KMT2AMAPTMEN1POLBLMNA | |
| SCHEMBL20913317 | 0.74 | MAPT (0.48) | KMT2AMAPTMEN1POLBSMN1; SMN2 | |
| SCHEMBL13316448 | 0.73 | ALDH1A1 (0.56) | KMT2AMAPTMEN1POLBLMNA | |
| SCHEMBL29136879 | 0.73 | KMT2A (0.42) | KMT2AMAPTMEN1POLBLMNA | |
| SCHEMBL29136877 | 0.73 | KMT2A (0.42) | KMT2AMAPTMEN1POLBLMNA | |
| SCHEMBL2912518 | 0.72 | KDR (0.57) | KMT2AMEN1POLBSMN1; SMN2SYK | |
| SCHEMBL899149 | 0.71 | TSHR (0.48) | KMT2AMAPTMEN1LMNAALDH1A1 | |
| SCHEMBL16876539 | 0.70 | MAP4K4 (0.61) | KMT2AMEN1POLBSYKGSK3B | |
| SCHEMBL31247411 | 0.69 | NPC1 (0.50) | KMT2AMEN1POLBSYKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |