Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 17/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.71 |
| ▸ | CDK1 | P06493 | 3/20 | 0.71 |
| ▸ | CDK4 | P11802 | 3/20 | 0.71 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.71 |
| ▸ | CCND1 | P24385 | 3/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.71 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.71 |
| ▸ | CDK9 | P50750 | 1/20 | 0.71 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.71 |
| ▸ | CCNE1 | P24864 | 17/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 16/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 15/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718025 | 0.90 | CDK2 (0.59) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3719472 | 0.90 | CDK2 (0.59) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL2914088 | 0.90 | CDK2 (0.58) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3715540 | 0.89 | CDK2 (0.57) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3718045 | 0.89 | CDK2 (0.59) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3793236 | 0.89 | CDK2 (0.57) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3799897 | 0.88 | CDK2 (0.56) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL18396867 | 0.87 | CDK2 (0.67) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL18396871 | 0.87 | CDK2 (0.67) | CDK2CCNA2CDK5CDK1CDK4 | |
| SCHEMBL3793439 | 0.86 | CDK2 (0.54) | CDK2CCNA2CDK5CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139288-A1 | 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS | C3 BIO GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | CBR3, DHFR, AKR1C3 | CDK2 685/4885CCNA2 767/4885CDK5 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.