Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | TXK | P42681 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.32 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29690734 | 1.00 | NEK2 (0.36) | NEK2MEN1POLBCYP3A4MAPT | |
| SCHEMBL29690741 | 0.90 | POLB (0.33) | NEK2MEN1POLBCYP3A4MAPT | |
| SCHEMBL29690975 | 0.88 | ITK (0.32) | NEK2POLBALDH1A1ITKTXK | |
| SCHEMBL29137807 | 0.88 | ITK (0.32) | NEK2POLBALDH1A1ITKTXK | |
| SCHEMBL29932902 | 0.77 | JAK3 (0.47) | ITKTXKJAK3BTK | |
| SCHEMBL5657783 | 0.77 | JAK3 (0.47) | ITKTXKJAK3BTK | |
| SCHEMBL20162005 | 0.71 | JAK3 (0.39) | ITKTXKJAK3BTK | |
| SCHEMBL20161728 | 0.71 | TXK (0.45) | NEK2HPGDALDH1A1ITKTXK | |
| SCHEMBL29932895 | 0.71 | TXK (0.45) | NEK2HPGDALDH1A1ITKTXK | |
| SCHEMBL20161423 | 0.70 | JAK3 (0.47) | ITKTXKJAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605404-B | Novel thiazole-containing compound, intermediate and application thereof | 合肥美诺医药有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-114605404-A | Novel thiazole-containing compound, intermediate and application thereof | 苏州美诺医药科技有限公司 | 2022-06-10 | — | — | CN | disclosed |