Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.57 |
| ▸ | CSF1R | P07333 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907886 | 0.93 | KCNH2 (0.67) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2912410 | 0.92 | KCNH2 (0.63) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2912766 | 0.92 | KCNH2 (0.68) | KCNH2SCN5ACSF1R | |
| SCHEMBL2912268 | 0.91 | KCNH2 (0.63) | KCNH2SCN5ACSF1RMAPTTHRB | |
| SCHEMBL2912865 | 0.90 | KCNH2 (0.67) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2912403 | 0.90 | KCNH2 (0.61) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2908740 | 0.89 | KCNH2 (0.64) | KCNH2SCN5ACSF1R | |
| SCHEMBL2912181 | 0.88 | KCNH2 (0.65) | KCNH2SCN5ACSF1RMAPT | |
| SCHEMBL2909867 | 0.88 | KCNH2 (0.72) | KCNH2SCN5ACSF1RMAPTTHRB | |
| SCHEMBL2912778 | 0.88 | KCNH2 (0.74) | KCNH2SCN5ACSF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |