Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28525720 | 0.86 | SLC18A3 (0.34) | MAPTSLC18A3CYP2D6CYP2C9MAPK1 | |
| SCHEMBL28528279 | 0.83 | CYP2D6 (0.38) | CYP2D6CYP2C9MAPK1CYP2C19HRH3 | |
| SCHEMBL28528284 | 0.83 | CYP2D6 (0.38) | CYP2D6CYP2C9MAPK1CYP2C19HRH3 | |
| SCHEMBL28909552 | 0.82 | HRH3 (0.41) | MAPTCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28909558 | 0.82 | HRH3 (0.41) | MAPTCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28522991 | 0.80 | RBP4 (0.41) | MAPTCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL24775580 | 0.79 | HRH3 (0.38) | MAPTCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28532862 | 0.78 | MAPT (0.41) | MAPTCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL31525091 | 0.77 | HTR2C (0.41) | SLC18A3CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28529794 | 0.77 | HTR2C (0.41) | SLC18A3CYP2D6CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |