Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.52 |
| ▸ | PKM | P14618 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16038295 | 0.82 | MAPT (0.52) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL16037364 | 0.82 | MAPT (0.52) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL16037367 | 0.82 | MAPT (0.52) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL30075005 | 0.79 | MAPT (0.60) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL16037476 | 0.79 | MAPT (0.60) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL1699987 | 0.79 | MAPT (0.60) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL523815 | 0.79 | MAPT (0.59) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL29387647 | 0.79 | MAPT (0.59) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL17071336 | 0.78 | MAPT (0.56) | MAPTPKMPOLBKMT2AMEN1 | |
| SCHEMBL16038916 | 0.78 | MAPT (0.53) | MAPTPKMPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |