Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 12/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL29142290 | 0.94 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Acetic Acid SCHEMBL29142369 | 0.92 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Acetic Acid SCHEMBL14251751 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Oxalic Acid SCHEMBL29142360 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Succinic Acid SCHEMBL29142343 | 0.89 | MEN1 (0.66) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Succinic Acid SCHEMBL29142340 | 0.88 | FDPS (0.40) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bicarbonate SCHEMBL29031702 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Glutarate SCHEMBL29142297 | 0.85 | MEN1 (0.64) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Succinic Acid SCHEMBL18575094 | 0.84 | MEN1 (0.55) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Acetic Acid SCHEMBL35016 | 0.83 | MEN1 (0.65) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440991-A | Polysiloxane composition | 默克专利有限公司 | 2024-01-23 | — | — | CN | disclosed |