Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2347535 | 0.96 | HSD17B10 (0.67) | HSD17B10MAPK1MAPK14MAPTNPC1 | |
| SCHEMBL2348950 | 0.91 | MAPK14 (0.69) | MAPK14MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2350063 | 0.79 | MAPK14 (0.64) | MAPK1MAPK14MAPTL3MBTL1NPC1 | |
| SCHEMBL4818436 | 0.77 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL2347043 | 0.76 | CA12 (0.51) | MAPK14MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2345355 | 0.75 | KDM4E (0.49) | HSD17B10MAPK1MAPK14MAPTNPC1 | |
| SCHEMBL11729204 | 0.74 | MEN1 (0.80) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10788595 | 0.73 | HSD17B10 (0.67) | HSD17B10MAPK1MAPTL3MBTL1NPC1 | |
| SCHEMBL2349306 | 0.73 | PDK1 (0.46) | MAPK14MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3955328 | 0.73 | MAPT (0.55) | MAPK14MAPTL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940786-B1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LTD (GB) | 2010-08-18 | — | — | EP | disclosed |